Pasteurellosis Vaccine Commercialization: Physiochemical Factors for Optimum Production

Pasteurella spp. are Gram-negative facultative bacteria that cause severe economic and animal losses. Pasteurella-based vaccines the most promising solution for controlling outbreaks. Remarkably, insufficient biomass cultivation (low cell viability productivity) lack of knowledge about process have impacted bulk production vaccines. Bioprocess optimization in shake flask bioreactor is required to improve efficiency while lowering costs. However, its state art limited providing insights on upscaling, preventing a cost-effective vaccine with mass-produced from being developed. In general, optimum spp., factors such as pH (6.0–8.2), agitation speed (90–500 rpm), temperature (35–40 °C) used yield. Hence, this review discusses strategy Mannheimia species can potentially be pasteurellosis. The physicochemical related operational parameter conditions bioprocess engineering perspective maximize yields minimized cost also covered, expectation facilitating commercialization process.